WP 6: In vivo effects in ecologically relevant biota

Studies: brown trout larvae exposed to citalopram, brown trout larvae exposed to venlafaxine, juvenile brown trout exposed to citalopram, juvenile brown trout exposed to venlafaxine

Assays: B-esterase activity brown trout larvae + CIT, B-esterase activity brown trout larvae + VEN, B-esterase activity juvenile brown trout + CIT, B-esterase activity juvenile brown trout + VEN, Hsp70 level juvenile brown trout + CIT, Hsp70 level juvenile brown trout + VEN, SOD activity brown trout larvae + VEN, SOD activity juvenile brown trout + VEN, behaviour during exposure brown trout larvae + CIT, behaviour during exposure brown trout larvae + VEN, behaviour during exposure juvenile brown trout + CIT, behaviour during exposure juvenile brown trout + VEN, behaviour in stressful environment juvenile brown trout + VEN, behaviour in stressful environment brown trout larvae + CIT, behaviour in stressful environment brown trout larvae + VEN, behaviour in stressful environment juvenile brown trout + CIT, behaviour of big ramshorn snail + VEN, chemical analysis brown trout larvae + VEN, chemical analysis juvenile brown trout + VEN, cortisol content juvenile brown trout + CIT, cortisol content juvenile brown trout + VEN, hatching rate brown trout larvae + CIT, heart rate brown trout larvae + CIT, histopathology brown trout larvae + CIT, histopathology brown trout larvae + VEN, histopathology juvenile brown trout + CIT, histopathology juvenile brown trout + VEN, mortality brown trout larvae + CIT, mortality juvenile brown trout + VEN, mortality, heart rate and hatching rate brown trout larvae + VEN, tissue analysis brown trout larvae + CIT, tissue analysis juvenile brown trout + CIT, water analysis brown trout larvae + CIT, water analysis juvenile brown trout + CIT, weight and legth juvenile brown trout + CIT, weight and length brown trout larvae + CIT, weight and length brown trout larvae + VEN, weight and length juvenile brown trout + VEN

Investigation: In vivo effects of Antidepressants

Assays: B-esterase activity juvenile brown trout + VEN, Hsp70 level juvenile brown trout + VEN, SOD activity juvenile brown trout + VEN, behaviour during exposure juvenile brown trout + VEN, behaviour in stressful environment juvenile brown trout + VEN, chemical analysis juvenile brown trout + VEN, cortisol content juvenile brown trout + VEN, histopathology juvenile brown trout + VEN, mortality juvenile brown trout + VEN, weight and length juvenile brown trout + VEN

Investigation: In vivo effects of Antidepressants

Assays: B-esterase activity brown trout larvae + VEN, SOD activity brown trout larvae + VEN, behaviour during exposure brown trout larvae + VEN, behaviour in stressful environment brown trout larvae + VEN, chemical analysis brown trout larvae + VEN, histopathology brown trout larvae + VEN, mortality, heart rate and hatching rate brown trout larvae + VEN, weight and length brown trout larvae + VEN

Investigation: In vivo effects of Antidepressants

Assays: B-esterase activity juvenile brown trout + CIT, Hsp70 level juvenile brown trout + CIT, behaviour during exposure juvenile brown trout + CIT, behaviour in stressful environment juvenile brown trout + CIT, cortisol content juvenile brown trout + CIT, histopathology juvenile brown trout + CIT, tissue analysis juvenile brown trout + CIT, water analysis juvenile brown trout + CIT, weight and legth juvenile brown trout + CIT

Investigation: In vivo effects of Antidepressants

Assays: B-esterase activity brown trout larvae + CIT, behaviour during exposure brown trout larvae + CIT, behaviour in stressful environment brown trout larvae + CIT, hatching rate brown trout larvae + CIT, heart rate brown trout larvae + CIT, histopathology brown trout larvae + CIT, mortality brown trout larvae + CIT, tissue analysis brown trout larvae + CIT, water analysis brown trout larvae + CIT, weight and length brown trout larvae + CIT

Investigation: In vivo effects of Antidepressants

Study: 1 hidden item

Organisms: No organisms

SOPs: No SOPs

Data files: 1 hidden item

Investigation: In vivo effects of Antidepressants

Study: brown trout larvae exposed to venlafaxine

Organisms: No organisms

SOPs: No SOPs

Data files: liver histopathology brown trout larvae and juv...

Investigation: In vivo effects of Antidepressants

Study: brown trout larvae exposed to venlafaxine

Organisms: No organisms

SOPs: No SOPs

Data files: B-esterase activity brown trout larvae and juve...

Investigation: In vivo effects of Antidepressants

Study: brown trout larvae exposed to venlafaxine

Organisms: No organisms

SOPs: No SOPs

Data files: SOD activity brown trout larvae and juveniles +...

Investigation: In vivo effects of Antidepressants

Study: juvenile brown trout exposed to venlafaxine

Organisms: No organisms

SOPs: No SOPs

Data files: SOD activity brown trout larvae and juveniles +...

Investigations: In vivo effects of Antidepressants

Studies: juvenile brown trout exposed to venlafaxine

Assays: SOD activity juvenile brown trout + VEN

Investigations: In vivo effects of Antidepressants

Studies: juvenile brown trout exposed to venlafaxine

Assays: B-esterase activity juvenile brown trout + VEN

Investigations: In vivo effects of Antidepressants

Studies: juvenile brown trout exposed to venlafaxine

Assays: Hsp70 level juvenile brown trout + VEN

Investigations: In vivo effects of Antidepressants

Studies: juvenile brown trout exposed to venlafaxine

Assays: histopathology juvenile brown trout + VEN

Investigations: In vivo effects of Antidepressants

Studies: brown trout larvae exposed to venlafaxine

Assays: histopathology brown trout larvae + VEN

DOI: 10.3389/fenvs.2020.586584

Citation: Front. Environ. Sci. 8 : 133

DOI: 10.1186/s12302-020-00437-z

Citation: Environ Sci Eur 32(1) : 134

PubMed ID: 32201650

Citation: PeerJ. 2020 Mar 12;8:e8765. doi: 10.7717/peerj.8765. eCollection 2020.

PubMed ID: 30595998

Citation: Environ Sci Eur. 2018;30(1):48. doi: 10.1186/s12302-018-0179-4. Epub 2018 Dec 7.

PubMed ID: 31338260

Citation: PeerJ. 2019 Jul 11;7:e7289. doi: 10.7717/peerj.7289. eCollection 2019.