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Created: 11th Dec 2019 at 13:06
Last updated: 17th Dec 2020 at 15:15
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In contrast to WP 5, which addresses in vivo effects in early developmental stages of zebrafish as an established model organism in ecotoxicology, WP 6 will use one indigenous fish species and one species representative of invertebrates in order to verify and, thus, validate the data obtained with zebrafish and also those generated at the in vitro levels (WPs 3 and 4) with respect to their ecologi-cal relevance. Possible adverse effects of the test substances identified in WP 1 will be assessed
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Organisms: Not specified
31.07.2018-23.08.2018; 0,1,10,100,1000 µg/L venlafaxine; 10Fish*3Replicate
Person responsible: Michael Ziegler
Snapshots: No snapshots
Investigation: In vivo effects of Antidepressants
Assays: B-esterase activity juvenile brown trout + VEN, Hsp70 level juvenile brown trout + VEN, SOD activity juvenile brown trout + VEN, behaviour during exposure juvenile brown trout + VEN, behaviour in stressful environment juvenile brown trout + VEN, chemical analysis juvenile brown trout + VEN, cortisol content juvenile brown trout + VEN, histopathology juvenile brown trout + VEN, mortality juvenile brown trout + VEN, weight and length juvenile brown trout + VEN
7°C: 15.01.2019-22.05.2019; 11°C 15.01.2019-29.04.2019; 0, 1, 10, 100, 1000 µg/L Venlafaxine; 30Fish*3Replicate
Person responsible: Michael Ziegler
Snapshots: No snapshots
Investigation: In vivo effects of Antidepressants
Assays: B-esterase activity brown trout larvae + VEN, SOD activity brown trout larvae + VEN, behaviour during exposure brown trout larvae + VEN, behaviour in stressful environment brown trout larvae + VEN, chemical analysis brown trout larvae + VEN, histopathology brown trout larvae + VEN, mortality, heart rate and hatching rate brown trout larvae + VEN, weight and length brown trout larvae + VEN
08.08.2017-04.09.2017
0,1,10,100,1000 µg/L CIT
10 fish*3 replicates*5 treatments
Person responsible: Michael Ziegler
Snapshots: No snapshots
Investigation: In vivo effects of Antidepressants
Assays: B-esterase activity juvenile brown trout + CIT, Hsp70 level juvenile brown trout + CIT, behaviour during exposure juvenile brown trout + CIT, behaviour in stressful environment juvenile brown trout + CIT, cortisol content juvenile brown trout + CIT, histopathology juvenile brown trout + CIT, tissue analysis juvenile brown trout + CIT, water analysis juvenile brown trout + CIT, weight and legth juvenile brown trout + CIT
11°C 28.12.2016-13.04.2017
7°C 28.12.2016-11.05.2017
0,1,10,100,1000 µg/L
30 fish*3 replicates*5 treatments
Person responsible: Michael Ziegler
Snapshots: No snapshots
Investigation: In vivo effects of Antidepressants
Assays: B-esterase activity brown trout larvae + CIT, behaviour during exposure brown trout larvae + CIT, behaviour in stressful environment brown trout larvae + CIT, hatching rate brown trout larvae + CIT, heart rate brown trout larvae + CIT, histopathology brown trout larvae + CIT, mortality brown trout larvae + CIT, tissue analysis brown trout larvae + CIT, water analysis brown trout larvae + CIT, weight and length brown trout larvae + CIT
Contributor: Michael Ziegler
Assay type: Verhalten
Technology type: Technology Type
Snapshots: No snapshots
Investigation: In vivo effects of Antidepressants
Study: 1 hidden item
Organisms: No organisms
SOPs: No SOPs
Data files: 1 hidden item
Contributor: Michael Ziegler
Assay type: Experimental Assay Type
Technology type: Technology Type
Snapshots: No snapshots
Investigation: In vivo effects of Antidepressants
Study: brown trout larvae exposed to venlafaxine
Organisms: No organisms
SOPs: No SOPs
Data files: liver histopathology brown trout larvae and juv...
Contributor: Michael Ziegler
Assay type: Experimental Assay Type
Technology type: Technology Type
Snapshots: No snapshots
Investigation: In vivo effects of Antidepressants
Study: brown trout larvae exposed to venlafaxine
Organisms: No organisms
SOPs: No SOPs
Data files: B-esterase activity brown trout larvae and juve...
Contributor: Michael Ziegler
Assay type: Experimental Assay Type
Technology type: Technology Type
Snapshots: No snapshots
Investigation: In vivo effects of Antidepressants
Study: brown trout larvae exposed to venlafaxine
Organisms: No organisms
SOPs: No SOPs
Data files: SOD activity brown trout larvae and juveniles +...
Contributor: Michael Ziegler
Assay type: Experimental Assay Type
Technology type: Technology Type
Snapshots: No snapshots
Investigation: In vivo effects of Antidepressants
Study: juvenile brown trout exposed to venlafaxine
Organisms: No organisms
SOPs: No SOPs
Data files: SOD activity brown trout larvae and juveniles +...
Creator: Michael Ziegler
Contributor: Michael Ziegler
Investigations: In vivo effects of Antidepressants
Creator: Michael Ziegler
Contributor: Michael Ziegler
Investigations: In vivo effects of Antidepressants
Creator: Michael Ziegler
Contributor: Michael Ziegler
Investigations: In vivo effects of Antidepressants
Creator: Michael Ziegler
Contributor: Michael Ziegler
Investigations: In vivo effects of Antidepressants
Creator: Michael Ziegler
Contributor: Michael Ziegler
Investigations: In vivo effects of Antidepressants
Abstract:
Authors: Michael Ziegler, Michel Banet, Rebecca Bauer, Heinz-R. Köhler, Sabine Stepinski, Selina Tisler, Carolin Huhn, Christian Zwiener, Rita Triebskorn
Date Published: 21st Jan 2021
Journal: Front. Environ. Sci.
DOI: 10.3389/fenvs.2020.586584
Citation: Front. Environ. Sci. 8 : 133
Abstract:
Authors: Michael Ziegler, Helene Eckstein, Shannon Ottmann, Lukas Reinelt, Sabine Stepinski, Heinz-R. Köhler, Rita Triebskorn
Date Published: 1st Dec 2020
Journal: Environ Sci Eur
DOI: 10.1186/s12302-020-00437-z
Citation: Environ Sci Eur 32(1) : 134
Abstract (Expand)
Authors: Michael Ziegler, Sarah Knoll, H. R. Kohler, Selina Tisler, Carolin Huhn, Christian Zwiener, Rita Triebskorn
Date Published: 24th Mar 2020
Journal: PeerJ
PubMed ID: 32201650
Citation: PeerJ. 2020 Mar 12;8:e8765. doi: 10.7717/peerj.8765. eCollection 2020.