WP 9: Data management, aggregation and analysis

All data from chemical and biological analyses will be used as sources of data for WP 9. It is not the purpose of Eff-Net to provide a tool to fully model the effects of carbohydrate metabolism-related and neurotoxic substances. Rather, in the sense of an Adverse Outcome Pathway (AOP [33]), the data pool will be analyzed for the suitability of lower scale data (e.g. receptor assay data) to predict the adverse outcome of the test substances at higher levels of organization (e.g. fish). In addition, multivariate statistics will help to analyze the significance of the multiple low-scale assays brought together within Eff-Net at the levels of both the individual and the population. In-depth analysis will help to establish intrinsic and plausible connections between the effects seen at different response levels.
The data aggregated in the Eff-Net database to be set up in this WP will add to form a basis for the future development of more complex future models suitable for the development of adverse out-comes of the exposure of aquatic organisms to environmental chemicals.