Sarah Knoll

This WP will provide data for receptor binding of the tested xenobiotics at a molecular level in cell-free systems, since in most cases the binding of a compound to a receptor molecule implicates a biological effect, either agonistic or antagonistic. However, since biological approaches are not ca-pable of identifying the chemical structures of environmental contaminants, feasible combinations of bioassays and chemical analysis will be developed and tested. As a pretreatment step concepts of an
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WP 1 first aims at identifying and quantifying relevant test substances from the groups of pharma-ceuticals (antidiabetics and neuroactive drugs such as selective serotonin reuptake inhibitors) and food additives (artificial sweeteners) in surface waters partly using existing expertise. The focus is on substances of high consumption and environmental relevance. Based on this analysis, the final test compounds will be defined (e.g. metformin, fluoxetine and sucralose), and specific methods for
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Effect-Net is a multi- and transdisciplinary project that intends to generate a toolbox for multi-scale chemical effects as a basis for a holistic effect-based risk evaluation, and for sociocultural governance aiming at personal and political responsibility as well as a reduction of emissions of hazardous chemicals into aquatic environments. The focus is on the development of a multi-scale network for the identification and evaluation of the biological hazards posed by emerging high-consumption
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