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WP 2 will address metabolites and transformation products (TPs) of compounds selected in WP 1. These will be generated and identified by means of electrochemical synthesis mimicking mainly Phase I metabolism and mass spectrometric detection. The mixture of metabolites and TPs will be used for ligand screening with nuclear receptors (WP 3) using the analytical methodology devel-oped as well as for further toxicity screening for effects on cells (WP 4) and in biota (WPs 5 and 6).
SEEK ID: https://effectnet-seek.bioquant.uni-heidelberg.de/projects/3
Public web page: Not specified
Organisms: No Organisms specified
Effect-Net PALs: No PALs for this Project
Project created: 6th Jul 2016
Related items
Projects: Effect-Net, WP 9: Data management, aggregation and analysis, WP 1: Chemical analyses of test substances in water and biota and bioanalytics of stress response, WP 5: In vivo effects in model fish embryos and larvae, WP 6: In vivo effects in ecologically relevant biota, WP 7: Community-relevant effects, WP 8: Tool boxes for effect-based risk assessment, WP 2: Generation and characterization of metabolites, WP 3: In vitro effects 1: Receptor binding in non-cellular systems, WP 4: In vitro effects 2: Fish cells, WP 10: Mapping of the actors involved in the evaluation of biological hazards in aquatic ecosystems, WP 11: Actor perceptions and elaboration of guidelines and recommendations
Institutions: Universität Heidelberg
https://orcid.org/0000-0002-1785-6759Coordinator Eff-Net
Projects: Effect-Net, WP 8: Tool boxes for effect-based risk assessment, WP 1: Chemical analyses of test substances in water and biota and bioanalytics of stress response, WP 2: Generation and characterization of metabolites, WP 3: In vitro effects 1: Receptor binding in non-cellular systems
Institutions: Karlsruhe Institute of Technology
Projects: Effect-Net, WP 9: Data management, aggregation and analysis, WP 1: Chemical analyses of test substances in water and biota and bioanalytics of stress response, WP 5: In vivo effects in model fish embryos and larvae, WP 7: Community-relevant effects, WP 8: Tool boxes for effect-based risk assessment, WP 2: Generation and characterization of metabolites, WP 3: In vitro effects 1: Receptor binding in non-cellular systems, WP 4: In vitro effects 2: Fish cells, WP 10: Mapping of the actors involved in the evaluation of biological hazards in aquatic ecosystems, WP 11: Actor perceptions and elaboration of guidelines and recommendations
Institutions: Universität Heidelberg
Projects: Effect-Net, WP 9: Data management, aggregation and analysis, WP 1: Chemical analyses of test substances in water and biota and bioanalytics of stress response, WP 5: In vivo effects in model fish embryos and larvae, WP 6: In vivo effects in ecologically relevant biota, WP 7: Community-relevant effects, WP 8: Tool boxes for effect-based risk assessment, WP 2: Generation and characterization of metabolites, WP 3: In vitro effects 1: Receptor binding in non-cellular systems, WP 4: In vitro effects 2: Fish cells, WP 10: Mapping of the actors involved in the evaluation of biological hazards in aquatic ecosystems, WP 11: Actor perceptions and elaboration of guidelines and recommendations
Institutions: Universität Heidelberg
Abstract (Expand)
Authors: Stefanie Jacob, A. Dotsch, Sarah Knoll, H. R. Kohler, Eike Rogall, D. Stoll, Selina Tisler, Carolin Huhn, Thomas Schwartz, Christian Zwiener, Rita Triebskorn
Date Published: 2019
Journal: Environ Sci Eur
PubMed ID: 30595998
Citation: Environ Sci Eur. 2018;30(1):48. doi: 10.1186/s12302-018-0179-4. Epub 2018 Dec 7.
Abstract (Expand)
Authors: Stefanie Jacob, Sarah Knoll, Carolin Huhn, H. R. Kohler, Selina Tisler, Christian Zwiener, Rita Triebskorn
Date Published: 25th Jul 2019
Journal: PeerJ
PubMed ID: 31338260
Citation: PeerJ. 2019 Jul 11;7:e7289. doi: 10.7717/peerj.7289. eCollection 2019.