WP 3: In vitro effects 1: Receptor binding in non-cellular systems
OverviewThis WP will provide data for receptor binding of the tested xenobiotics at a molecular level in cell-free systems, since in most cases the binding of a compound to a receptor molecule implicates a biological effect, either agonistic or antagonistic. However, since biological approaches are not ca-pable of identifying the chemical structures of environmental contaminants, feasible combinations of bioassays and chemical analysis will be developed and tested. As a pretreatment step concepts of an effect-directed fractionation of the water samples could be applied [67].
SEEK ID: https://effectnet-seek.bioquant.uni-heidelberg.de/projects/4
Public web page: Not specified
Organisms: No Organisms specified
Effect-Net PALs: No PALs for this Project
Project created: 6th Jul 2016
Related items
Projects: Effect-Net, WP 9: Data management, aggregation and analysis, WP 1: Chemical analyses of test substances in water and biota and bioanalytics of stress response, WP 5: In vivo effects in model fish embryos and larvae, WP 6: In vivo effects in ecologically relevant biota, WP 7: Community-relevant effects, WP 8: Tool boxes for effect-based risk assessment, WP 2: Generation and characterization of metabolites, WP 3: In vitro effects 1: Receptor binding in non-cellular systems, WP 4: In vitro effects 2: Fish cells, WP 10: Mapping of the actors involved in the evaluation of biological hazards in aquatic ecosystems, WP 11: Actor perceptions and elaboration of guidelines and recommendations
Institutions: Universität Heidelberg
https://orcid.org/0000-0002-1785-6759
Coordinator Eff-Net
Projects: Effect-Net, WP 8: Tool boxes for effect-based risk assessment, WP 1: Chemical analyses of test substances in water and biota and bioanalytics of stress response, WP 2: Generation and characterization of metabolites, WP 3: In vitro effects 1: Receptor binding in non-cellular systems
Institutions: Karlsruhe Institute of Technology
Projects: Effect-Net, WP 9: Data management, aggregation and analysis, WP 1: Chemical analyses of test substances in water and biota and bioanalytics of stress response, WP 5: In vivo effects in model fish embryos and larvae, WP 7: Community-relevant effects, WP 8: Tool boxes for effect-based risk assessment, WP 2: Generation and characterization of metabolites, WP 3: In vitro effects 1: Receptor binding in non-cellular systems, WP 4: In vitro effects 2: Fish cells, WP 10: Mapping of the actors involved in the evaluation of biological hazards in aquatic ecosystems, WP 11: Actor perceptions and elaboration of guidelines and recommendations
Institutions: Universität Heidelberg
Projects: Effect-Net, WP 9: Data management, aggregation and analysis, WP 1: Chemical analyses of test substances in water and biota and bioanalytics of stress response, WP 5: In vivo effects in model fish embryos and larvae, WP 6: In vivo effects in ecologically relevant biota, WP 7: Community-relevant effects, WP 8: Tool boxes for effect-based risk assessment, WP 2: Generation and characterization of metabolites, WP 3: In vitro effects 1: Receptor binding in non-cellular systems, WP 4: In vitro effects 2: Fish cells, WP 10: Mapping of the actors involved in the evaluation of biological hazards in aquatic ecosystems, WP 11: Actor perceptions and elaboration of guidelines and recommendations
Institutions: Universität Heidelberg
