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Created: 11th Dec 2019 at 13:12
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In contrast to WP 5, which addresses in vivo effects in early developmental stages of zebrafish as an established model organism in ecotoxicology, WP 6 will use one indigenous fish species and one species representative of invertebrates in order to verify and, thus, validate the data obtained with zebrafish and also those generated at the in vitro levels (WPs 3 and 4) with respect to their ecologi-cal relevance. Possible adverse effects of the test substances identified in WP 1 will be assessed
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Public web page: Not specified
Organisms: Not specified
Snapshots: No snapshots
Studies: brown trout larvae exposed to citalopram, brown trout larvae exposed to venlafaxine, juvenile brown trout exposed to citalopram, juvenile brown trout exposed to venlafaxine
Assays: B-esterase activity brown trout larvae + CIT, B-esterase activity brown trout larvae + VEN, B-esterase activity juvenile brown trout + CIT, B-esterase activity juvenile brown trout + VEN, Hsp70 level juvenile brown trout + CIT, Hsp70 level juvenile brown trout + VEN, SOD activity brown trout larvae + VEN, SOD activity juvenile brown trout + VEN, behaviour during exposure brown trout larvae + CIT, behaviour during exposure brown trout larvae + VEN, behaviour during exposure juvenile brown trout + CIT, behaviour during exposure juvenile brown trout + VEN, behaviour in stressful environment juvenile brown trout + VEN, behaviour in stressful environment brown trout larvae + CIT, behaviour in stressful environment brown trout larvae + VEN, behaviour in stressful environment juvenile brown trout + CIT, behaviour of big ramshorn snail + VEN, chemical analysis brown trout larvae + VEN, chemical analysis juvenile brown trout + VEN, cortisol content juvenile brown trout + CIT, cortisol content juvenile brown trout + VEN, hatching rate brown trout larvae + CIT, heart rate brown trout larvae + CIT, histopathology brown trout larvae + CIT, histopathology brown trout larvae + VEN, histopathology juvenile brown trout + CIT, histopathology juvenile brown trout + VEN, mortality brown trout larvae + CIT, mortality juvenile brown trout + VEN, mortality, heart rate and hatching rate brown trout larvae + VEN, tissue analysis brown trout larvae + CIT, tissue analysis juvenile brown trout + CIT, water analysis brown trout larvae + CIT, water analysis juvenile brown trout + CIT, weight and legth juvenile brown trout + CIT, weight and length brown trout larvae + CIT, weight and length brown trout larvae + VEN, weight and length juvenile brown trout + VEN
11°C 28.12.2016-13.04.2017
7°C 28.12.2016-11.05.2017
0,1,10,100,1000 µg/L
30 fish*3 replicates*5 treatments
Person responsible: Michael Ziegler
Snapshots: No snapshots
Investigation: In vivo effects of Antidepressants
Assays: B-esterase activity brown trout larvae + CIT, behaviour during exposure brown trout larvae + CIT, behaviour in stressful environment brown trout larvae + CIT, hatching rate brown trout larvae + CIT, heart rate brown trout larvae + CIT, histopathology brown trout larvae + CIT, mortality brown trout larvae + CIT, tissue analysis brown trout larvae + CIT, water analysis brown trout larvae + CIT, weight and length brown trout larvae + CIT
one week before end of experiment daily 3 photos of the photographable tanks were made and the sojourn of the fish in the upper and lower aquaria part were analysed
Contributor: Michael Ziegler
Assay type: Verhalten
Technology type: Technology Type
Snapshots: No snapshots
Investigation: In vivo effects of Antidepressants
Study: brown trout larvae exposed to citalopram
Organisms: Salmo trutta
SOPs: No SOPs
Data files: behaviour during exposure brown trout larvae + CIT
Abstract (Expand)
Authors: Michael Ziegler, Sarah Knoll, H. R. Kohler, Selina Tisler, Carolin Huhn, Christian Zwiener, Rita Triebskorn
Date Published: 24th Mar 2020
Journal: PeerJ
PubMed ID: 32201650
Citation: PeerJ. 2020 Mar 12;8:e8765. doi: 10.7717/peerj.8765. eCollection 2020.