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SEEK: a systems biology data and model management platform

Abstract (Expand)

BACKGROUND: Systems biology research typically involves the integration and analysis of heterogeneous data types in order to model and predict biological processes. Researchers therefore require tools ...

Authors: K. Wolstencroft, S. Owen, O. Krebs, Q. Nguyen, N. J. Stanford, M. Golebiewski, A. Weidemann, M. Bittkowski, L. An, D. Shockley, J. L. Snoep, W. Mueller, C. Goble

Date Published: 11th Jul 2015

Journal: BMC Syst Biol

PubMed ID: 26160520

Citation: BMC Syst Biol. 2015 Jul 11;9:33. doi: 10.1186/s12918-015-0174-y.

Created: 6th Jul 2016 at 13:27

Spurenstoffeinträge in Gewässer: Der Einfluss von Vertrauen in Akteure auf die Problemwahrnehmung

Effect-Net

Abstract (Expand)

Die Verunreinigung von Gewässern in Deutschland ist wieder zunehmend Gegen-stand der öffentlichen und politischen Debatte. Ende des 20. Jahrhunderts galt das Problem durch gesetzgeberisches Handeln auf ...

Authors: Simon Schaub, Jale Tosun

Date Published: 7th Jun 2019

Journal: Zeitschrift für Umweltpolitik und Umweltrecht

Citation:

Created: 5th Jun 2019 at 08:45

Effektstudien in der Risikobewertung: Das Projekt Effect-Net und Ergebnisse des Workshops

Effect-Net

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Abstract (Expand)

Die Untersuchung der Effekte von Chemikalien auf Organismen ist essentieller Bestandteil in der Umweltrisikobewertung. Hierfür werden standardisierte Tests eingesetzt; daneben existieren aber zahlreiche ...

Authors: Rita Triebskorn, Ulrike Scherer, Thomas Braunbeck

Date Published: 13th Aug 2019

Journal: Korrespondenz Wasserwirtschaft

Citation: Korrespondenz Wasserwirtschaft, 8/2019 Seite 445-449

Created: 13th Aug 2019 at 08:25

Effects of guanylurea, the transformation product of the antidiabetic drug metformin, on the health of brown trout (Salmo trutta f. fario).

WP 1: Chemical analyses of test substances in water and biota and bioanalytics of stress response, WP 2: Generation and characterization of metabolites, WP 6: In vivo effects in ecologically relevant biota

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Abstract (Expand)

Background: Guanylurea is the main transformation product of the antidiabetic drug metformin, which is one of the most prescribed pharmaceuticals worldwide. Due to the high rate of microbial degradation ...

Authors: Stefanie Jacob, Sarah Knoll, Carolin Huhn, H. R. Kohler, Selina Tisler, Christian Zwiener, Rita Triebskorn

Date Published: 25th Jul 2019

Journal: PeerJ

PubMed ID: 31338260

Citation: PeerJ. 2019 Jul 11;7:e7289. doi: 10.7717/peerj.7289. eCollection 2019.

Created: 1st Oct 2019 at 13:38

Does the antidiabetic drug metformin affect embryo development and the health of brown trout (Salmo trutta f. fario)?

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Abstract (Expand)

Background: Due to the rising number of type 2 diabetes patients, the antidiabetic drug, metformin is currently among those pharmaceuticals with the highest consumption rates worldwide. Via sewage-treatment ...

Authors: Stefanie Jacob, A. Dotsch, Sarah Knoll, H. R. Kohler, Eike Rogall, D. Stoll, Selina Tisler, Carolin Huhn, Thomas Schwartz, Christian Zwiener, Rita Triebskorn

Date Published: 2019

Journal: Environ Sci Eur

PubMed ID: 30595998

Citation: Environ Sci Eur. 2018;30(1):48. doi: 10.1186/s12302-018-0179-4. Epub 2018 Dec 7.

Created: 1st Oct 2019 at 14:12

Time-course of coiling activity in zebrafish (Danio rerio) embryos exposed to ethanol as an endpoint for developmental neurotoxicity (DNT) - Hidden potential and underestimated challenges.

Effect-Net

Abstract (Expand)

Detection of developmental neurotoxicity (DNT) has been recognized as a major challenge by regulatory bodies and science. In search of sensitive and specific test methods, spontaneous tail coiling of ...

Authors: Florian Zindler, Franziska Beedgen, Thomas Braunbeck

Date Published: 21st Jun 2019

Journal: Chemosphere

PubMed ID: 31254777

DOI: 10.1016/j.chemosphere.2019.06.154

Citation: Chemosphere. 2019 Nov;235:12-20.

Created: 11th Oct 2019 at 12:45

Analysis of tail coiling activity of zebrafish (Danio rerio) embryos allows for the differentiation of neurotoxicants with different modes of action

Effect-Net

Abstract (Expand)

In (eco)toxicology, there is a critical need for efficient methods to evaluate the neurotoxic potential of environmental chemicals. Recent studies proposed analysis of early coiling activity in zebrafish ...

Authors: Florian Zindler, Franziska Beedgen, Diana Brandt, Madeleine Steiner, Daniel Stengel, Lisa Baumann, Thomas Braunbeck

Date Published: 9th Oct 2019

Journal: Ecotoxicology and Environmental Safety

DOI: 10.1016/j.ecoenv.2019.109754

Citation:

Created: 11th Oct 2019 at 13:00

Impact of the antidepressant citalopram on the behaviour of two different life stages of brown trout.

Effect-Net, WP 6: In vivo effects in ecologically relevant biota

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Abstract (Expand)

Background: Over the last two decades, there has been a constant increase in prescription rates of antidepressants. In parallel, neuroactive pharmaceuticals are making their way into aquatic environments ...

Authors: Michael Ziegler, Sarah Knoll, H. R. Kohler, Selina Tisler, Carolin Huhn, Christian Zwiener, Rita Triebskorn

Date Published: 24th Mar 2020

Journal: PeerJ

PubMed ID: 32201650

Citation: PeerJ. 2020 Mar 12;8:e8765. doi: 10.7717/peerj.8765. eCollection 2020.

Created: 7th Jul 2020 at 12:41

Norfluoxetine Is the Only Metabolite of Fluoxetine in Zebrafish (Danio rerio) Embryos That Accumulates at Environmentally Relevant Exposure Scenarios.

Effect-Net

Abstract (Expand)

Fluoxetine has been recognized as one of the most toxic pharmaceuticals in the aquatic environment. Since there is growing evidence that the toxic potential of fluoxetine in surface waters is markedly ...

Authors: F. Zindler, S. Tisler, A. K. Loerracher, C. Zwiener, T. Braunbeck

Date Published: 7th Apr 2020

Journal: Environ Sci Technol

PubMed ID: 32167300

Citation: Environ Sci Technol. 2020 Apr 7;54(7):4200-4209. doi: 10.1021/acs.est.9b07618. Epub 2020 Mar 13.

Created: 29th Sep 2020 at 12:30

Transition towards sustainable pharmacy? The influence of public debates on policy responses to pharmaceutical contaminants in water

Effect-Net, WP 10: Mapping of the actors involved in the evaluation of biological hazards in aquatic ecosystems

Abstract (Expand)

Background Despite clear-cut scientific evidence for pharmaceutical contaminants causing adverse effects in aquatic life, the regulatory response in Germany has been weak. In principle, there are ...

Authors: Simon Schaub, Thomas Braunbeck

Date Published: 1st Dec 2020

Journal: Environ Sci Eur

DOI: 10.1186/s12302-020-00423-5

Citation: Environ Sci Eur 32(1) : 107

Created: 23rd Nov 2020 at 11:01, Last updated: 23rd Nov 2020 at 11:04

Comparing Discourse and Policy Network Approaches: Evidence from Water Policy on Micropollutants

Effect-Net, WP 10: Mapping of the actors involved in the evaluation of biological hazards in aquatic ecosystems

Abstract (Expand)

To understand how actors make collective policy decisions, scholars use policy and discourse network approaches to analyze interdependencies among actors. While policy networks often build on survey ...

Authors: Simon Schaub, Florence Metz

Date Published: 2nd Jun 2020

Journal: PaG

DOI: 10.17645/pag.v8i2.2597

Citation: PaG 8(2) : 184

Created: 23rd Nov 2020 at 11:28, Last updated: 23rd Nov 2020 at 11:29

What determines regulatory preferences? Insights from micropollutants in surface waters

Effect-Net

Abstract (Expand)

The ever-increasing consumption of pharmaceuticals, cosmetics, detergents and food additives puts aquatic ecosystems under strain. Accordingly, respective regulation of micropollutants in surface waters ...

Authors: Jale Tosun, Simon Schaub, Andreas Fleig

Date Published: 1st Apr 2020

Journal: Environmental Science & Policy

DOI: 10.1016/j.envsci.2020.02.001

Citation: Environmental Science & Policy 106 : 136

Created: 23rd Nov 2020 at 11:46, Last updated: 23rd Nov 2020 at 11:48

Do environmentally relevant concentrations of fluoxetine and citalopram impair stress-related behavior in zebrafish (Danio rerio) embryos?

WP 1: Chemical analyses of test substances in water and biota and bioanalytics of stress response

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Abstract (Expand)

Selective serotonin reuptake inhibitors (SSRIs) have been shown to interfere with various physiological functions of aquatic organisms, yet the neuroactive potential of low concentrations of SSRIs in ...

Authors: Florian Zindler, Saskia Stoll, Lisa Baumann, Sarah Knoll, Carolin Huhn, Thomas Braunbeck

Date Published: 1st Dec 2020

Journal: Chemosphere

DOI: 10.1016/j.chemosphere.2020.127753

Citation: Chemosphere 261 : 127753

Created: 2nd Dec 2020 at 09:58, Last updated: 28th Jan 2021 at 12:40

Biochemical and cellular biomarkers in brown trout (Salmo trutta f. fario) in response to the antidepressants citalopram and venlafaxine

Effect-Net, WP 6: In vivo effects in ecologically relevant biota

Abstract:

Not specified

Authors: Michael Ziegler, Helene Eckstein, Shannon Ottmann, Lukas Reinelt, Sabine Stepinski, Heinz-R. Köhler, Rita Triebskorn

Date Published: 1st Dec 2020

Journal: Environ Sci Eur

DOI: 10.1186/s12302-020-00437-z

Citation: Environ Sci Eur 32(1) : 134

Created: 17th Dec 2020 at 09:26, Last updated: 17th Dec 2020 at 09:30

Civil Society and the Governance of Water Services: German Political Parties’ Reactions to Right2Water

Effect-Net, WP 11: Actor perceptions and elaboration of guidelines and recommendations

Abstract (Expand)

The European Citizens’ Initiative (ECI) Right2Water asked for guaranteed water quality and quantity all over Europe, and demanded that water services remain in the hands of public entities. Support for ...

Authors: Jale Tosun, Rita Triebskorn

Date Published: 6th Mar 2020

Journal: Water (ISSN 2073-4441; CODEN: WATEGH)

DOI: 10.3390/w12030743

Citation:

Created: 25th Feb 2021 at 09:47

The impact of the anti-diabetic drug metformin on the intestinal microbiome of larval brown trout (Salmo trutta f. fario)

WP 1: Chemical analyses of test substances in water and biota and bioanalytics of stress response

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Abstract (Expand)

The anti-diabetic pharmaceutical metformin is frequently analysed in the aquatic environment. Its impact on the fish microbiome is studied to get a deeper knowledge about the consequence of the metformin ...

Authors: Eike Rogall, Thomas Schwartz, Stefanie Jacob, Rita Triebskorn

Date Published: 22nd Apr 2020

Journal: Environmental Sciences Europe

DOI: 10.1186/s12302-020-00341-6

Citation:

Created: 25th Feb 2021 at 10:10

Behavioral and Developmental Changes in Brown Trout After Exposure to the Antidepressant Venlafaxine

WP 6: In vivo effects in ecologically relevant biota

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Abstract:

Not specified

Authors: Michael Ziegler, Michel Banet, Rebecca Bauer, Heinz-R. Köhler, Sabine Stepinski, Selina Tisler, Carolin Huhn, Christian Zwiener, Rita Triebskorn

Date Published: 21st Jan 2021

Journal: Front. Environ. Sci.

DOI: 10.3389/fenvs.2020.586584

Citation: Front. Environ. Sci. 8 : 133

Created: 10th Mar 2021 at 09:11, Last updated: 10th Mar 2021 at 09:15