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Created: 11th Dec 2019 at 13:41
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In contrast to WP 5, which addresses in vivo effects in early developmental stages of zebrafish as an established model organism in ecotoxicology, WP 6 will use one indigenous fish species and one species representative of invertebrates in order to verify and, thus, validate the data obtained with zebrafish and also those generated at the in vitro levels (WPs 3 and 4) with respect to their ecologi-cal relevance. Possible adverse effects of the test substances identified in WP 1 will be assessed
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Organisms: Not specified
Snapshots: No snapshots
Studies: brown trout larvae exposed to citalopram, brown trout larvae exposed to venlafaxine, juvenile brown trout exposed to citalopram, juvenile brown trout exposed to venlafaxine
Assays: B-esterase activity brown trout larvae + CIT, B-esterase activity brown trout larvae + VEN, B-esterase activity juvenile brown trout + CIT, B-esterase activity juvenile brown trout + VEN, Hsp70 level juvenile brown trout + CIT, Hsp70 level juvenile brown trout + VEN, SOD activity brown trout larvae + VEN, SOD activity juvenile brown trout + VEN, behaviour during exposure brown trout larvae + CIT, behaviour during exposure brown trout larvae + VEN, behaviour during exposure juvenile brown trout + CIT, behaviour during exposure juvenile brown trout + VEN, behaviour in stressful environment juvenile brown trout + VEN, behaviour in stressful environment brown trout larvae + CIT, behaviour in stressful environment brown trout larvae + VEN, behaviour in stressful environment juvenile brown trout + CIT, behaviour of big ramshorn snail + VEN, chemical analysis brown trout larvae + VEN, chemical analysis juvenile brown trout + VEN, cortisol content juvenile brown trout + CIT, cortisol content juvenile brown trout + VEN, hatching rate brown trout larvae + CIT, heart rate brown trout larvae + CIT, histopathology brown trout larvae + CIT, histopathology brown trout larvae + VEN, histopathology juvenile brown trout + CIT, histopathology juvenile brown trout + VEN, mortality brown trout larvae + CIT, mortality juvenile brown trout + VEN, mortality, heart rate and hatching rate brown trout larvae + VEN, tissue analysis brown trout larvae + CIT, tissue analysis juvenile brown trout + CIT, water analysis brown trout larvae + CIT, water analysis juvenile brown trout + CIT, weight and legth juvenile brown trout + CIT, weight and length brown trout larvae + CIT, weight and length brown trout larvae + VEN, weight and length juvenile brown trout + VEN
08.08.2017-04.09.2017
0,1,10,100,1000 µg/L CIT
10 fish*3 replicates*5 treatments
Person responsible: Michael Ziegler
Snapshots: No snapshots
Investigation: In vivo effects of Antidepressants
Assays: B-esterase activity juvenile brown trout + CIT, Hsp70 level juvenile brown trout + CIT, behaviour during exposure juvenile brown trout + CIT, behaviour in stressful environment juvenile brown trout + CIT, cortisol content juvenile brown trout + CIT, histopathology juvenile brown trout + CIT, tissue analysis juvenile brown trout + CIT, water analysis juvenile brown trout + CIT, weight and legth juvenile brown trout + CIT
Contributor: Michael Ziegler
Assay type: Experimental Assay Type
Technology type: Technology Type
Snapshots: No snapshots
Investigation: In vivo effects of Antidepressants
Study: juvenile brown trout exposed to citalopram
Organisms: No organisms
SOPs: No SOPs
Data files: water analysis juvenile brown trout + CIT
Abstract (Expand)
Authors: Michael Ziegler, Sarah Knoll, H. R. Kohler, Selina Tisler, Carolin Huhn, Christian Zwiener, Rita Triebskorn
Date Published: 24th Mar 2020
Journal: PeerJ
PubMed ID: 32201650
Citation: PeerJ. 2020 Mar 12;8:e8765. doi: 10.7717/peerj.8765. eCollection 2020.