Controlled Vocabularies and Ontologies
SysMO-DB recommends that consortium members use identifiers from public databases and terms from community ontologies wherever possible when describing and annotating data and models. The following table shows the resources available for annotation by biological object category. These are the resources recommended by SysMO-DB and also represent the most commonly used in the SysMO consortium.
| Entity | Resource | Example ID | Database URL | MIRIAM URN |
|---|---|---|---|---|
| Protein | UNIPROT | P23470 | http://www.ebi.uniprot.org | urn:miriam:uniprot |
| Chemical | ChEBI | CHEBI:17234 | http://www.ebi.ac.uk/chebi/ | urn:miriam:obo.chebi |
| Chemical | KEGG Compund | C0003 | http://www.genome.jp/kegg/ligand.html | urn:miriam:kegg.compound |
| Chemical | PubChem | CID:24749 | http://pubchem.ncbi.nlm.nih.gov/ |
urn:miriam:pubchem.compound |
| Reaction Kinetics | SABIO-RK | 20936 | http://sabio.villa-bosch.de/ | urn:miriam:sabiork.reaction |
| Enzymes | Enzyme Nomenclature (EC) IntEnz | EC 1.14.13.39 | http://www.ebi.ac.uk/intenz/ | urn:miriam:ec-code |
| Pathways | KEGG Pathways | map00480 | http://www.genome.jp/kegg/pathway.html | urn:miriam:kegg.pathway |
| Cellular Location | Gene Ontology | GO:0016020 | http://www.geneontology.org/ | urn:miriam:obo.go |
| Molecular Function | Gene Ontology | GO:0004857 | http://www.geneontology.org/ | urn:miriam:obo.go |
| Biological Process | Gene Ontology | GO:0071581 | http://www.geneontology.org/ | urn:miriam:obo.go |
| Literature | PubMed | PMID:19112082 | http://www.ncbi.nlm.nih.gov/pubmed/ | urn:miriam:pubmed |
| Model Descriptions | Systems Biology Ontology | SBO:0000244 | http://www.ebi.ac.uk/sbo/ | urn:miriam:biomodels.sbo |
Assistance with Data and Models Annotation
Accessing and navigating these resources can be difficult and time-consuming for large data sets. SysMO-DB provide tools to make data and model annotation easier.
RightField
RightField (http://www.rightfield.org.uk) allows the easy annotation of excel spreadsheet data with terms from community ontologies. Relevant ranges of ontology terms can be embedded into spreadsheets in specific cells as simple drop-down lists. This allows consistent and standards-compliant annotation without the need to browse or navigate the ontologies.
Multiple ontologies can be used in the same spreadsheet, and the sources of each term and the version of each ontology is automatically collected and recorded.
A collection of SysMO templates have already been RightField-enabled. These templates are available for download from the templates page and from the SysMO-DB project in the SEEK.
JWS OneStop
OneStop assists with model annotation and publishing. It is a one-stop-shop for producing a MIRIAM-compliant, annotated model in SBML. OneStop extracts the names used for species and reactions in an uploaded model and uses these names to search public databases for the official terms and MIRIAM identifiers. It uses the Semantic SBML web service (http://semanticsbml.org/) for searching and returns a list of possible matches that the modellers can select from. This ensures the accuracy of each annotation whilst providing an easy mechanism for identifying possible matches.
In addition to annotations, OneStop also provides editing and validation functionality as well as automatically exporting models in SBGN.
